23 CBD Experts & Enthusiasts Reveal the Potential CBD Effects Consumers Should Be Aware Of

By April 16, 2021 June 18th, 2021 No Comments
Potential CBD Effects Consumers Should Know About

If you’ve never used CBD before, you might be wondering what it feels like and if CBD gets you high. While CBD is non-psychoactive, meaning that it doesn’t get you high, it does have a number of other potential effects that consumers should be aware of. Some consumers seeking relief from conditions such as anxiety turn to CBD for its possible anxiety-reducing effects, while those who are taking CBD during the day may be concerned that it will make them sleepy, making it more difficult to focus on the tasks at hand.

The potential effects of CBD vary from person to person, as well as whether an individual is taking any other prescribed or over the counter medications. Regardless of the reason you’re considering taking CBD, there are some potential effects to be aware of. To learn more about the possible effects of CBD, we reached out to a panel of CBD experts and enthusiasts and asked them to answer this question:

“What are some CBD effects consumers should be aware of?”

Meet Our Panel of CBD Experts & Enthusiasts:

●      Logan Derrick

●      Melanie Ruth

●      Dr. Leslie Apgar

●      Ashwinn Krishnaswamy

●      Chris Vaughn

●      David Anthony Schroeder

●      Tim McCarthy

●      Anthony Franciosi

●      Daniel Perez Vidal

●      Stephanie Johnson

●      AJ Payack

●      Colin Kelley

●      Jasmine Khachatrian

●      Simon Elkjær


●      Shawn Lockery

●      Brighid Kelley

●      Seth Richtsmeier

●      Dr. Johnny Garcia

●      Rex Freiberger

●      Degelis Tufts Pilla

●      Wilfred Waimiri

●      Galvé Deleste

Read on to learn what our experts had to say about the potential effects of CBD that you should be aware of.

NOTE: The information and opinions expressed below represent the opinions of the individual contributors and do not necessarily reflect the opinions of Incredible Edibles.

Logan Derrick

Logan Derrick is the co-owner of Steel Wellness, a brand focused on premium-grade health products and mindful wellness education. Logan is a successful health & wellness writer with helpful content in publications all across the internet.

“The effects of CBD greatly rely on the quality and overall purity of the product…”

It is also important to be aware of whether the CBD you are using contains THC, which can cause the “high” that is often related to other types of cannabis. Many reliable CBD providers offer products that contain no THC, still offering the same benefits without causing the high.

Melanie Ruth


Melanie Ruth is the Head of PR & Business Development at Where’s Weed, a website that helps people find cannabis businesses in their local community. Their business connects medical and recreational cannabis users with trusted providers, giving people access to real company reviews, menus, and current deals near them.

“As people search for CBD, they are generally looking for help with chronic pain, anxiety, depression, and other health concerns…”

It has also been proven to help with epileptic seizures, which currently remains the only FDA-approved treatment for CBD. But as additional studies are conducted, people are also seeing the positive effects CBD can have on heart health, acne, and other physical and mental ailments.

Dr. Leslie Apgar

Dr. Leslie Apgar is a board-certified OBGYN with 20 years of experience in direct patient care. She has a passion for helping patients find ease and health through quality medical cannabis and natural medicine. She is also the co-founder and medical director of Greenhouse Wellness, a medical cannabis dispensary, as well as Co-Founder of Blissiva, a female-focused cannabis line. Dr. Apgar is also the Founder of PuraVida, a Maryland-based cosmetic spa and laser center, which continues to thrive well into its 10th year of operation.

“CBD in smaller doses is good at treating anxiety…”

In larger doses it is useful for those suffering from sleep disorders, and in very high doses (Epidiolex) it is useful in reducing resistant seizures that plague those with certain severe epileptic seizure disorders. CBD does not cause intoxication like its cousin, THC. Even at very high doses, the only side effects will be to make you sleepy. CBD is broken down by the liver and competes with the same metabolic pathway as most other medications that we take routinely, so for those patients on seizure medication and certain blood thinners, we often recommend to stagger their CBD doses from their other medications to be on the safe side.

CBD’s effects sneak up on the user. I often tell patients that they won’t notice a change in their symptoms until 10-14 days. Sometimes, patients don’t think they are any better after first starting CBD, and they stop taking it only to call me and confess that they are now so much worse. Unlike common OTC pain medications that we take that make us feel better in about 20 minutes, I counsel patients that CBD works over time at reducing overall inflammation in the body. So daily intake in smaller amounts is the best way o achieve a reduction in inflammation. The effects can be boosted depending on how CBD is ingested. The bioavailability is much greater if it is inhaled or vaped versus being consumed orally. The topical administration is surprisingly helpful, and patients are happy to know that it doesn’t cross the bloodstream at all, as many topical preparations also contain THC.

Ashwinn Krishnaswamy

Ashwinn is the co-founder of Oklahoma Smokes. He also runs a digital agency, Forge, that helps launch new products and brands.

“The most common side effects of CBD use are drowsiness, diarrhea, dry mouth, and nausea…”

But these vary from person to person, and most people who try out CBD won’t need to rush straight into the bathroom. I’d actually be more concerned with the quality of the CBD you’re buying, rather than the side effects of CBD itself. A lot of companies will lie about the amount of CBD in their products or the amount of THC present in their products. There are plenty of brands that are completely reputable and honest, but you need to be doing your own due diligence to make sure you’re getting the CBD product that you’ve paid for.

Chris Vaughn


Chris Vaughn is a seasoned entrepreneur and leader in the tech, beverage alcohol, and cannabis industries. He’s the CEO of Pacific Consolidated Holdings (PCH), which owns and operates businesses across the Cannabis and BevAlc industries. PCH’s signature platforms include Emjay, one of the leading cannabis delivery and retail operators in California, and Saucey, one of the largest last-mile logistics and delivery platforms for alcohol in the U.S.

“Although CBD is by and large safe to use, there’s a reason the FDA has made it illegal to market CBD as a dietary supplement—there’s still a lot we don’t know…”

It is possible to be allergic to CBD, just like it’s possible to be allergic to hemp or cannabis. It can also affect the efficacy of prescription drugs. If you know that you’re taking a daily medication, you should always talk to your doctor before adding something new to your wellness routine. Even though CBD is great for most people and I do highly recommend trying it out, you know your individual risk profile better than anyone and should do your own research to determine if CBD is right for you. CBD is usually well-tolerated in adults, and potential side effects are often limited to dry mouth, diarrhea, reduced appetite, or fatigue.

David Anthony Schroeder


David Anthony Schroeder is one of the nation’s foremost advocates for the use of cannabidiol (CBD) for therapeutic pain management. Mr. Schroeder is an autodidactic expert of CBD out of personal necessity. After struggling for 50 years with chronic pain, David stumbled upon a CBD pain stick—which led the way to his immersive quest in the CBD arena. David is the author of the book, 7 ways to manage pain with CBD, a book hailed as the CBD pain management bible.

“There are a couple of things to be aware of with CBD…”

Occasionally there have been some who have had an allergic reaction, but that number is so small at the moment that there is no evidence to corroborate or invalidate how many people that may apply to. For those who don’t have an immediate adverse reaction to CBD, there are some things that people need to be aware of.

Taking too much CBD oil at one time could cause indigestion. This would be like drinking six ounces or more of CBD oil. Generally, there would be no need to do something like that, except under physician care. One of the more significant side effects of too much CBD would be drowsiness, dry mouth, and possibly diarrhea. Also, depending on a person’s tolerance to narcotics or alcohol, they may not feel the intended effect. These users would need a higher dose to achieve the desired result.

But a word of warning. Some users are making a huge mistake. They are taking CBD and not talking to their doctors or speaking directly with a cannabis doctor. They’re mixing CBD with their prescriptions. There are a lot of unknowns with CBD and other drug interactions.

Think of CBD as a boss. If used regularly, CBD takes control of the liver and stops it from processing some drugs, such as heart medications. The toxicity can build up in a person’s bloodstream, which could lead to injury and possibly even death.

The world health organization stated in their 2018 preliminary CBD report that CBD is generally well tolerated with a good safety profile. Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications. To date, there is no evidence of recreational use of CBD or any public health-related problems associated with the use of pure CBD.

Tim McCarthy


Tim McCarthy is the VP of Sales at United Natural Hemp Extracts.

“The effects that you get from any hemp extract will vary by the amount you take and what else is ‘riding along’ with the CBD molecule…”

Many things amend the effect of hemp on the endocannabinoid system, such as:

  • A first-time user
  • How you take it:
    • Tinctures (sublingual absorption—possibly faster)
    • Capsules or consumables—chew and swallow (must first pass liver elimination—possibly slower)
    • Topicals for localized use
  • The dosage (10mg to 50mg)
  • The CBD source (isolate, distillate, or crude)
  • Synergistic and synchronized added ingredients (with or without terpenes and/or other botanicals for complimentary benefits)

First-time users sometimes report a sense of light-headedness, but this is probably the result of experiencing the effects of supplementing their endocannabinoid system for the first time. Many report feeling nothing at all. This can be a result of some products having little to no actual CBD in them or a low-dosage isolate. Products on the shelf with incorrect dosages have slipped by due to the newness of the CBD market.

There are great companies with great products out there. They have nothing to hide and readily show off the evidence behind all their hard work. Yet with so many new companies and products in the market, federal and state regulators may not be able to keep up with each one in a timely manner. Therefore, fact checking is up to you: caveat emptor. It is still up to the consumer to confirm that the manufacturer has done their due diligence to assure the product’s potency, purity, and safety.

In 2021, consumers can expect to find targeted product innovations that speak to a specific desired experience and ones that are focused on their particular need states, like stress or anxiety. Attention to terpene blends by effect can greatly focus the experience to your individual needs. Some terpenes, like linalool found in lavender, are known to promote stress relief and relaxation, while others like pinene and limonene potentially promote focus and uplifting effects, and there are dozens of key terpenes with thousands of combination possibilities. Start looking for and requesting a more specific experience. Now, one cannot expect, nor will you see, federally sanctioned indications, but by looking for specialized CBD blends based upon that interplay of terpenes and cannabinoids, consumers should get their expectations better matched to their needs and leave behind one size fits most products.

Anthony Franciosi

Anthony Franciosi is the founder of Honest Marijuana Company, which utilizes all-natural cultivation methods to produce only the finest organic and eco-conscious cannabis products. Anthony has shared his industry and cultivation insights for many top cannabis outlets, including Cannabis Business Times, Marijuana Venture, and High Times.

“CBD has a wide range of medical benefits…”

Chief among those benefits are:

  • Reduces nausea and vomiting (antiemetic)
  • Fights tumor and cancer cells (antitumoral)
  • Suppresses seizure activity (anticonvulsant)
  • Combats anxiety and depression (anxiolytic)
  • Mediates psychotic disorders (antipsychotic)
  • Tempers neurodegenerative disorders (antioxidant)
  • Mitigates inflammatory disorders (anti-inflammatory)

In addition, CBD counteracts many of the intoxicating effects of THC like drowsiness, paranoia, and memory loss. In essence, CBD keeps THC from running amok in your system.

Disorders That Can Be Treated With CBD Effects

Because CBD has medicinal properties such as anticonvulsant, anxiolytic, and antiemetic, it can be used to treat a wide range of disorders. Four major disorders that can be treated with CBD are schizophrenia and other psychoses, epileptic disorders, anxiety, and depression.

Other disorders that may respond well to CBD treatment include cancer, osteoporosis, lupus, diabetes, obsessive compulsive disorder (OCD), Parkinson’s disease, and chronic and neuropathic pain. Science has yet to probe deeply into the use of CBD specifically for the treatment of these disorders because of the plant’s illegality. But as laws change, no doubt more and more studies will show what early reports conclude: CBD is a valuable medical compound.

Are There Any Side Effects Of CBD?

Though the scientific community hasn’t yet stated categorically that CBD is 100% safe, many studies have shown just that. CBD has been shown to have no effect on food intake, heart rate, body temperature, or blood pressure. It has been shown to affect the salivary glands resulting in dry mouth.

In addition, CBD inhibits liver enzymes that are responsible for metabolizing most of the drugs humans take. If you are on any medications, be sure to ask your doctor about possible interactions before taking CBD or a high-CBD product.

Whether or not dry mouth and the ability to metabolize medication could be considered side effects depends on the person who experiences them. Dry mouth may be a small price to pay for a reduction in pain or psychosis. And if CBD does better at fighting your nausea than your medication, it might be worth stopping the medication altogether. But it is best to discuss the possibilities with your doctor before discontinuing any medication.

Daniel Perez Vidal


Daniel Perez Vidal is the founder of for the Ageless and Professor of Social Entrepreneurship at Hult.

“We’ve found that approximately 1 out of 100 customers will report a side effect…”

Like the ones we list here.

Oftentimes, the individual will be one with high sensitivity to supplements/medication or heavily medicated. When we realized the importance of this, we decided to warn customers on every product page (under Precautions) and have researched and written an article on interactions also.

For instance, we had a long-term customer benefiting from CBD who had to stop taking it because she was put on the antibiotic clarithromycin for treating an infection. The good news is once she stopped using the medication, she was able to go back to CBD and its benefits.

Stephanie Johnson


Stephanie Johnson is a vocal advocate for CBD and Cannabinoid wellness and has been since the plant entered her life 10 years ago—when she faced stage 3 breast cancer. She speaks regularly through her broadcast at and writes at

“Too often people assume that it’s like other holistic remedy ideas but CBD—Cannabidiol—is an active compound like all of the cannabinoids are…”

They have receptors that they bind to in the ECS, and that encourages a response. Each person’s makeup is different. Each person’s needs are different. Because of those variables, it is important to remember that CBD isn’t for everyone. Of course, a large swath of the population has found benefit in it. People like me.

When consuming CBD, there can be multiple things to pay attention to and, again, it depends on body type and how much was enjoyed, etc.

  • Relaxation – Many consumers choose CBD because it can encourage a sense of relaxation.
  • Sleepiness – Naturally, this can help encourage sleep.
  • Motility – CBD can encourage metabolism and subsequent motility of eliminating waste. A good indicator that one has enjoyed too much CBD—and has gone outside of their therapeutic window—is they may get a stomach ache or endure diarrhea.
  • Immune system – Some folks with autoimmune disorders where the immune system is hyperactive, and homeostasis (balance) is actually not desired, may want to avoid CBD. Because CBD encourages homeostasis and can encourage the immune system (CB2 receptors in immune cells), then encouraging that system may not be desired.

Of course, it is always important to talk to your doctor and be in communication with your physician about these things.

AJ Payack


AJ Payack is the President of Vermont Organic Science Inc.

“CBD affects everybody differently…”

Some of our customers report that it’s amazing to help with sleep. Some say that it gives them a calm energy. The one thing that I would like to mention that it is possible to fail a drug test using CBD. If a consumer uses a full spectrum CBD product, there is THC in the product. It is under 0.3% THC, but there is enough in there to fail a drug test. If a consumer is worried about failed drug tests, they should be looking to purchase isolate or broad spectrum products. Make sure to look over the certificate of analysis.

Another thing consumers should be aware of is if a CBD oil product is certified organic or not. The hemp plant is an excellent absorber of pesticides and heavy metals. They used hemp to clean up the disaster in Chernobyl. With certified organic CBD products, you don’t have to worry about concentrated levels of pesticides or heavy metals.

Colin Kelley

Colin Kelley is the President at SOAR™.

“Whether you’re new to CBD or an experienced user, it isn’t always easy to see some of the more subtle effects of CBD…”

You may have experienced relaxation, reduced stress, or even better sleeping habits, but there’s so much more to this incredible cannabinoid (and its friends, CBG and CBN) than meets the eye. CBD, CBG, and CBN are all compounds derived from cannabis that interact with your body’s endocannabinoid system (ECS) when consumed or applied to the skin.

The ECS controls all kinds of bodily functions, including mood, sleep, appetite regulation, immune response, and more. By influencing these functions through the introduction of cannabinoids, the hope is that we can trigger certain receptors within the ECS to promote homeostasis and overall wellness.

CBD is the go-to cannabinoid, more easily produced and touting a wide variety of potential benefits, including pain relief, stress reduction, and better sleeping habits. Research suggests it may also have the ability to soothe sore muscles and relieve inflammation, which would make it perfect for athletes or those in recovery from surgery or injury.

CBG and CBN are lesser-known cousins of CBD and THC, but they’ve been making waves in the industry. CBG is gaining traction for its potential to enhance energy and focus, as it seems to interact with your CB1 and CB2 cell receptors (those are part of your ECS!) more powerfully than CBD. CBN, on the other hand, is being studied more for its potential as a sleep aid, antibacterial agent, and anti-inflammatory—talk about a triple threat!

But the best part about these compounds? They’re all non-psychoactive, meaning you can enjoy all the benefits without having to worry about mind-altering effects. These compounds are also well-known for having minimal side effects. You may experience fatigue or drowsiness when taking CBD, CBG, or CBN products, but that might be more helpful than harmful, depending on how you’re using them.

Jasmine Khachatrian


Jasmine Khachatrian is the Founder and President of Kanavia Organics, an online shop selling organic, medicinal-grade hemp products such as oils, salves, and soft gel capsules. All products contain 0% THC. The hemp is grown organically in America, and all products are made in FDA-inspected facilities.

“The more research conducted looking into this incredible plant, and…”

The more CBD products are being bought and consumed, the more we realize that there are little to no negative side effects for an individual who consumes CBD. However, like with most things, pinpointing the impact of CBD depends entirely on the individual.

CBD, or cannabidiol, is the second most prevalent in the active ingredients in the cannabis plant. Unlike its THC (tetrahydrocannabinol) counterpart, it doesn’t produce any feeling of euphoria. So it will not make you ‘high.’ To add to the statement that it cannot harm, a report from the WHO even stated that CBD exhibits no risk of abuse or dependence potential. There is no evidence of public health-related problems associated with the use of CBD.

CBD products come in various forms, including oils, gummies, and topicals, so the time of onset in an individual can vary. However, one thing that remains the same across the board is the positive effect it has: CBD is known to induce feelings of calmness, keeping anxiety at bay, which leads to better sleep. It’s used in treating epilepsy syndromes and may offer an alternative to medication in treating different types of chronic pain. Overall, CBD is the natural, healing, and calming elixir you didn’t know you needed.

Simon Elkjær


Simon Elkjær is the Chief Marketing Officer of avXperten, home of Denmark’s most affordable electronics. He has more than a decade’s worth of experience in e-commerce and marketing, five years of experience as an entrepreneur, and has even dabbled in public speaking.

“One CBD effect that customers should be more aware of is how it helps alleviate anxiety…”

Anxiety is something that most people are suffering from, especially during times like this when the pandemic is still very much among us. If used with the right diet and sleep routine, CBD can help rid you of anxiety and help you power through difficult times.

Shawn Lockery


Shawn Lockery is the Co-founder and CTO of InVivo Biosystems.

“The most common side effects that are experienced when someone uses too much CBD are…”

  • Drowsiness & fatigue
  • Low blood pressure
  • Dizziness
  • Fatigue
  • Change in the metabolism of medication
  • Lightheadedness

It is recommended to start with a small serving size of 5-15mg of CBD a maximum of three times per day and gradually increase the serving size to avoid experiencing any side effects.

Brighid Kelley


Brighid Kelley is the Chief Operating Officer at incann, a female-owned and operated CBD company based in Connecticut. She has been working in the cannabis/CBD industry for four years, and one of her first jobs in cannabis was research.

“While researching, I discovered a potential issue when it comes to CBD use and anticoagulants…”

And I think that it hasn’t gotten enough attention, as anticoagulants (blood thinners) are one of the most highly prescribed medications in the United States. I decided to focus on Warfarin, as it is the most highly prescribed anticoagulant across the US.

Here is the information that I found regarding CBD and Warfarin and potential interactions between the two:

Every year millions of people in the United States take anticoagulants, widely known as blood thinners. The most commonly prescribed anticoagulant is a drug called Warfarin, but despite its popularity, many people are unaware of how CBD and anticoagulants can impact one another when taken together.

Warfarin has two main isoforms (S and R) that are metabolized through the CYP hepatic enzyme complex. S-Warfarin is predominantly metabolized via the enzyme CYP2C9, while CYP3A4 is the dominant enzyme responsible for breaking down R-Warfarin.

Similar to Warfarin, CBD is processed by way of the CYP enzyme complex. There are seven major isoforms involved in CBD metabolism, five of which are involved in breaking down Warfarin, mainly CYP2C9 and CYP3A4. Because of this, CBD and anticoagulants like Warfarin must compete for enzymes in the same metabolic pathway in order to metabolize. CBD is a more potent competitor of the two, and so the CBD molecules bind first, leaving behind an excess of Warfarin in the system that didn’t get broken down. Over time, Warfarin in an individual’s system can build up. So while these two compounds don’t necessarily interact, they do affect each other. When there is a build-up of anticoagulants in someone’s system from daily use, it can lead to a rise in Internal Normalized Ratio (INR). When INR is too low, blood clots are not prevented, (which is why an anticoagulant like Warfarin would be prescribed). When INR is too high, there is an increased risk for bleeding.

Anyone who wants the benefits of CBD but is taking Warfarin should consult their doctors and closely monitor INR. Anyone taking medication should always consult their health practitioner before implementing CBD into a daily routine.

Seth Richtsmeier


Seth Richtsmeier is the Associate Director of SEO at Cannabis Creative Group. He brings an analytical mindset to the cannabis industry that truly drives ROI for businesses of all types, from cultivators to dispensaries to ancillary service providers. A seasoned expert in search engine optimization, Seth has provided companies with cutting-edge SEO programs and insights they need to grow.

“The first thing to keep in mind is that while it’s true that some people experience effects right away from taking CBD, this is not always the case…”

Just like many other nutritional products, it may be a week or two of using CBD daily before you see any kind of impact.

Secondly, CBD doesn’t get you high like the other popular compound, tetrahydrocannabinol (THC). You shouldn’t expect any psychoactive effects with CBD.

The most common effects and results that many CBD users report include anxiety relief, pain relief, better quality sleep, and reduced inflammation.

The most effective method of taking CBD depends on what type of relief you’re seeking. For instance, a muscle salve likely won’t help you with stress or anxiety, whereas a tincture could. On the other hand, that same salve could provide relief for sore muscles or an aching back.

There are also negative side effects of CBD, which may include nausea, fatigue, and irritability. CBD can actually raise levels of other medications in your blood (if you’re taking other medication) in the same way that grapefruit juice can. Take the start low, go slow approach. The FDA has yet to approve CBD as safe due to gaps in current knowledge on potential side effects.

Dr. Johnny Garcia


Dr. Garcia is the founder of Nimbus Health Systems and serves as the CEO of Cativa CBD. His pioneering work in medical training simulations, enterprise architecture, and unmanned systems has led to numerous awards across the country. He holds degrees from Old Dominion University (PhD Modeling and Simulation), St. Leo College (BA and BS), and the Florida Institute of Technology (MS and MBA).

“First, let’s talk about safety…

Studies find regular use (and even high daily doses of CBD) are resoundingly safe for the user. Dosage, formulation, and testing are of paramount importance, and picking the right brand and product is also crucial. Determining your reason for CBD use will assist in selecting a cream vs. a tincture or oil vs. a gum.

There are several formulations of CBD—isolate, full-spectrum, and broad-spectrum—and each one brings unique things to the table for the user. Here at Cativa CBD, we use all three formulations across our products because we believe that consumers should have their choice of formulation without sacrificing the quality of the product. Though most people generally tolerate the effects of CBD without issue, people on certain medications might experience detrimental side effects like extreme fatigue. Before you start using a CBD product, you should check with your healthcare provider to make sure that it is safe to use with your medications.

Rex Freiberger


Rex is the CEO of License to Vape, a top lifestyle publication featuring the latest vaping news and reviews.

“CBD can be great for treating many different types of pain…”

Some people find it useful for reducing stress and anxiety or for getting more restful sleep, too. But there are lesser-known properties of CBD and studies being done all the time. One noted, for example, the CBD reduced psychotic episodes in individuals diagnosed with schizophrenia.

It can be effective in controlling substance abuse, as well, by modifying the neural receptors that respond to opium. Opioid drug addiction in rats has been controlled by the use of CBD, reducing opioid-seeking behavior significantly.

Degelis Tufts Pilla


Degelis is an investor, entrepreneur, and plant-based medicine enthusiast. Before launching the Tribe family of brands, she was the COO of several other startups including Instafluence, the first influencer agency, which sold to Maker Studios in 2015.

“Many people think that CBD makes you tired since so many people take it to get a more restful sleep at night…”

However, there is no clinical evidence that CBD is a sleep aid—but it DOES diminish the anxiety that can inhibit sleep. CBD can work as an adaptogen, normalizing your bodily systems when they are out of whack in either direction, whether you need sleep or more energy.

Wilfred Waimiri

Wilfred Waimiri is a writer and editor who has spent the past three years working in the Cannabis and CBD industry. After working as the lead Cannabis writer at Thought Collect, Wilfred joined Imaginal as the SVP Research and Development. Wilfred uses his journalistic background to find and highlight the most interesting cannabis research and stories.

“Although CBD is safe and generally well-tolerated, it does have some side effects that consumers should be aware of…”

A literature review by Marilyn A. Huestis et al. found that, in humans, CBD can cause:

  • Hepatic abnormalities
  • Weight gain
  • Drowsiness
  • Diarrhea
  • Nausea
  • Vomiting
  • Appetite changes

They also identified that CBD could interact with various drugs, which was the focus of a paper by Joshua D. Brown and Almut G. Winterstein. Several of the interactions they identified include transaminase elevations, sedation, sleep disturbances, infection, and anemia.

Abundant caution should be taken when people with preexisting liver injuries, such as alcoholics, people with hepatitis, or people taking medication that can cause liver injury, are taking CBD. Some medicines that might cause liver injury include antiepileptics, antipsychotics, acetaminophen, certain antibiotics (e.g., amoxicillin and nitrofurantoin), antifungals, and verapamil.

Additionally, a literature review by Kerstin Iffland and Franjo Grotenhermen found that although CBD is generally safe, gaps exist in our knowledge on several important toxicological parameters that must be addressed. This includes identifying whether CBD interacts with hormones and identifying the effects of long-term CBD dosing on the immune system. Further research also needs to be done on the genotoxicity of CBD.

Galvé Deleste

Galvé Deleste is the Director of Marketing & Sales at BeLeaf Life’s Oils.

“CBD can make you sleepy…”

Some folks are looking for this effect as many have trouble getting a good night’s rest, but it could be problematic if it’s not the desired result. With ECO Therapy’s Rest CBD mints, you know exactly what you are getting yourself into, or rather what you should avoid if you’re trying to stay awake.